Purely comic book wise, is there anyone who could defeat Apocalypse solo?

[mj fan]

maybe Gladiator and Hyperion , Black bolt
Eternity, Thanos, The Living Tribunal, Ego the Living Planet for sure

[chuckhole]

Squirrel Girl. She's already taken down Doctor Doom, Modok, Terrax and Thanos, so Pocky shouldn't be too much of a stretch.

Right you are! Her power set should include being unbeatable against extreme level opponents.

[cyadin]

Blackbolt could just scream in his ear and boom, no more head or city they are fighting in:) Also i bet sentry can take him

[Teancum]

Squirrel Girl.  She's beaten like everyone, and she rules.

[Noscho]

Silver Surfer and Proteus, I guess. But since Proteus needs a "host", I dunno it will count as solo.

[Jeanfan321]

Dark phoenix will just melt him in a split second

[mj fan]

The Beyonder, Cosmic Spider-Man, Celestial...

[vengance777]

The Beyonder and Galactus can defeat him easily

[tymaca321]

Scarlet Witch, i mean she caused M day. So Apoc shouldnt be a problem for her
Jeannie/Dark Phoenix Dont need a reason i guess
Rogue, she beated him in X-men Evelution
Gambit at full power, poke *bam*
Galactus

Lotsa peeps could beat him
Including squirrels and ducks

Howard the Duck you ROCK!

[Lieutenant#61]

If invisible woman got better control of her powers I bet She take him down

[MarvelFan12345]

I'm going to make a new list.

Jean and all her children (Rachel, Nate Grey, Stryfe, and Cable if he could use his powers to the fullest)
Scarlet Witch
Franklin Richards
Galactus
Thanos
Vulcan
Hulk
Thor
Onslaught
Sentry
Beyonder
Captain Marvel
Silver Surfer
Magneto
Polaris

???
Dr. Strange
Magik
Rogue
Storm
Iceman
Elixir
Quasar
Nova

So quite a few actually and maybe even several more.